SOCS3 regulates CD8 T cell proliferation by inhibition of IL-6 and IL-27
نویسندگان
چکیده
St Vincent’s Institute, Fitzroy, VIC 3065, Australia, Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3168, Australia, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, VIC 3050, Australia, Amgen, One Amgen Centre Drive, Thousand Oaks, CA 91320, USA and Ludwig Institute for Cancer Research, Parkville, VIC 3050, Australia
منابع مشابه
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
Suppressor of cytokine signaling (SOCS) proteins regulate the intensity and duration of cytokine responses. SOCS3 is expressed in peripheral T cells, and recent reports have suggested that overexpression of SOCS3 modulates antigen- and/or costimulation-induced T-cell activation. To study the role of SOCS3 in the regulation of T-cell activation, we used a conditional gene-targeting strategy to g...
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